I also experienced the same as you when I added the hot key full
screen. I noticed that on the bottom of the screen I had to click about a ¼”
above where I was wanting to click. Like on the ball spin, and meter I had to
click above it to get it to work.
What I did to fix this was I moved my task bar to the side,
and did the Ctrl + F, then I moved it back to the bottom and did the Ctrl + F. This
fixed it on my computer. Hope it helps.